origin recognition complex, subunit 2
Symbol
Organism
Description
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| orc-2 | Caenorhabditis elegans | |
| Orc2 | Drosophila melanogaster | |
| zgc:153041 | Danio rerio | |
| Orc2 | Mus musculus | |
| Orc2 | Rattus norvegicus | |
| ORC2 | Saccharomyces cerevisiae | |
| orc2 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000075 | cell cycle checkpoint | biological_process | |
| GO:0000082 | G1/S transition of mitotic cell cycle | biological_process | |
| GO:0000084 | S phase of mitotic cell cycle | biological_process | |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0000216 | M/G1 transition of mitotic cell cycle | biological_process | |
| GO:0000278 | mitotic cell cycle | biological_process | |
| GO:0006260 | DNA replication | biological_process | |
| GO:0006270 | DNA-dependent DNA replication initiation | biological_process | |
| GO:0000792 | heterochromatin | cellular_component | |
| GO:0000808 | origin recognition complex | cellular_component | |
| GO:0000939 | condensed chromosome inner kinetochore | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005664 | nuclear origin of replication recognition complex | cellular_component | |
| GO:0003688 | DNA replication origin binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |