neurotrophic tyrosine kinase, receptor, type 3

Symbol

NTRK3 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Orthologs

SymbolSpecies
ntrk3a Danio rerio
Ntrk3 Mus musculus
Ntrk3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2819 Gene expression of NTRK3 increases with age Molecular adipose tissue Human NTRK3 —

GO Terms

GO IDGO TermGO Category
GO:0001764 neuron migration biological_process
GO:0006950 response to stress biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007399 nervous system development biological_process
GO:0019056 modulation by virus of host transcription biological_process
GO:0030154 cell differentiation biological_process
GO:0042490 mechanoreceptor differentiation biological_process
GO:0045471 response to ethanol biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0048665 neuron fate specification biological_process
GO:0048678 response to axon injury biological_process
GO:0048691 positive regulation of axon extension involved in regeneration biological_process
GO:0048712 negative regulation of astrocyte differentiation biological_process
GO:0051412 response to corticosterone stimulus biological_process
GO:0060548 negative regulation of cell death biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0090102 cochlea development biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005030 neurotrophin receptor activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0043121 neurotrophin binding molecular_function