solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Symbol
SLC11A2
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| Slc11a2 | Mus musculus | |
| Slc11a2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001666 | response to hypoxia | biological_process | |
| GO:0003032 | detection of oxygen | biological_process | |
| GO:0006783 | heme biosynthetic process | biological_process | |
| GO:0006811 | ion transport | biological_process | |
| GO:0006824 | cobalt ion transport | biological_process | |
| GO:0006825 | copper ion transport | biological_process | |
| GO:0006828 | manganese ion transport | biological_process | |
| GO:0006879 | cellular iron ion homeostasis | biological_process | |
| GO:0006919 | activation of caspase activity | biological_process | |
| GO:0007611 | learning or memory | biological_process | |
| GO:0010039 | response to iron ion | biological_process | |
| GO:0010042 | response to manganese ion | biological_process | |
| GO:0010288 | response to lead ion | biological_process | |
| GO:0015675 | nickel ion transport | biological_process | |
| GO:0015676 | vanadium ion transport | biological_process | |
| GO:0015684 | ferrous iron transport | biological_process | |
| GO:0015692 | lead ion transport | biological_process | |
| GO:0015992 | proton transport | biological_process | |
| GO:0034599 | cellular response to oxidative stress | biological_process | |
| GO:0035434 | copper ion transmembrane transport | biological_process | |
| GO:0035444 | nickel ion transmembrane transport | biological_process | |
| GO:0046686 | response to cadmium ion | biological_process | |
| GO:0048813 | dendrite morphogenesis | biological_process | |
| GO:0048821 | erythrocyte development | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0060586 | multicellular organismal iron ion homeostasis | biological_process | |
| GO:0070574 | cadmium ion transmembrane transport | biological_process | |
| GO:0070627 | ferrous iron import | biological_process | |
| GO:0071421 | manganese ion transmembrane transport | biological_process | |
| GO:0071577 | zinc ion transmembrane transport | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005764 | lysosome | cellular_component | |
| GO:0005765 | lysosomal membrane | cellular_component | |
| GO:0005769 | early endosome | cellular_component | |
| GO:0005770 | late endosome | cellular_component | |
| GO:0005773 | vacuole | cellular_component | |
| GO:0005802 | trans-Golgi network | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0005903 | brush border | cellular_component | |
| GO:0009986 | cell surface | cellular_component | |
| GO:0012505 | endomembrane system | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016324 | apical plasma membrane | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0031902 | late endosome membrane | cellular_component | |
| GO:0045177 | apical part of cell | cellular_component | |
| GO:0045178 | basal part of cell | cellular_component | |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
| GO:0055037 | recycling endosome | cellular_component | |
| GO:0070826 | paraferritin complex | cellular_component | |
| GO:0005215 | transporter activity | molecular_function | |
| GO:0005375 | copper ion transmembrane transporter activity | molecular_function | |
| GO:0005384 | manganese ion transmembrane transporter activity | molecular_function | |
| GO:0005385 | zinc ion transmembrane transporter activity | molecular_function | |
| GO:0005506 | iron ion binding | molecular_function | |
| GO:0005507 | copper ion binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0015078 | hydrogen ion transmembrane transporter activity | molecular_function | |
| GO:0015085 | calcium ion transmembrane transporter activity | molecular_function | |
| GO:0015086 | cadmium ion transmembrane transporter activity | molecular_function | |
| GO:0015087 | cobalt ion transmembrane transporter activity | molecular_function | |
| GO:0015093 | ferrous iron transmembrane transporter activity | molecular_function | |
| GO:0015094 | lead ion transmembrane transporter activity | molecular_function | |
| GO:0015099 | nickel ion transmembrane transporter activity | molecular_function | |
| GO:0015100 | vanadium ion transmembrane transporter activity | molecular_function | |
| GO:0015295 | solute:hydrogen symporter activity | molecular_function | |
| GO:0016151 | nickel ion binding | molecular_function | |
| GO:0022890 | inorganic cation transmembrane transporter activity | molecular_function | |
| GO:0030145 | manganese ion binding | molecular_function | |
| GO:0046870 | cadmium ion binding | molecular_function | |
| GO:0050897 | cobalt ion binding | molecular_function | |
| GO:0070835 | chromium ion transmembrane transporter activity | molecular_function | |