aconitase 1, soluble
Symbol
Organism
Description
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| aco-1 | Caenorhabditis elegans | |
| Irp-1A | Drosophila melanogaster | |
| aco1 | Danio rerio | |
| Aco1 | Mus musculus | |
| Aco1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006099 | tricarboxylic acid cycle | biological_process | |
| GO:0006101 | citrate metabolic process | biological_process | |
| GO:0006417 | regulation of translation | biological_process | |
| GO:0006879 | cellular iron ion homeostasis | biological_process | |
| GO:0008152 | metabolic process | biological_process | |
| GO:0009791 | post-embryonic development | biological_process | |
| GO:0010040 | response to iron(II) ion | biological_process | |
| GO:0010468 | regulation of gene expression | biological_process | |
| GO:0050892 | intestinal absorption | biological_process | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0003994 | aconitate hydratase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0016829 | lyase activity | molecular_function | |
| GO:0030350 | iron-responsive element binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0048027 | mRNA 5'-UTR binding | molecular_function | |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | molecular_function | |
| GO:0052632 | citrate hydro-lyase (cis-aconitate-forming) activity | molecular_function | |
| GO:0052633 | isocitrate hydro-lyase (cis-aconitate-forming) activity | molecular_function | |