myosin, heavy chain 11, smooth muscle

Symbol

MYH11 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
myh11a Danio rerio
Myh11 Mus musculus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006936 muscle contraction biological_process
GO:0006939 smooth muscle contraction biological_process
GO:0007411 axon guidance biological_process
GO:0008152 metabolic process biological_process
GO:0030241 skeletal muscle myosin thick filament assembly biological_process
GO:0048251 elastic fiber assembly biological_process
GO:0048739 cardiac muscle fiber development biological_process
GO:0001725 stress fiber cellular_component
GO:0005829 cytosol cellular_component
GO:0005859 muscle myosin complex cellular_component
GO:0016459 myosin complex cellular_component
GO:0030485 smooth muscle contractile fiber cellular_component
GO:0032982 myosin filament cellular_component
GO:0042470 melanosome cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003774 motor activity molecular_function
GO:0003779 actin binding molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008307 structural constituent of muscle molecular_function