myeloid differentiation primary response 88

Symbol

MYD88 (may also be known as: None)

Organism

Human

Description

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Orthologs

SymbolSpecies
Myd88 Drosophila melanogaster
myd88 Danio rerio
Myd88 Mus musculus
Myd88 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2216 myeloid differentiation primary response gene (88) increases with age Molecular hippocampus Human MYD88 59.3% Increase Gene Expression Level
DAA2230 myeloid differentiation primary response gene (88) increases with age Molecular parietal lobe Human MYD88 54.8% Increase Gene Expression Level
DAA2242 myeloid differentiation primary response gene (88) increases with age Molecular frontal lobe Human MYD88 58.7% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002238 response to molecule of fungal origin biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0006916 anti-apoptosis biological_process
GO:0007165 signal transduction biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0009615 response to virus biological_process
GO:0016064 immunoglobulin mediated immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032494 response to peptidoglycan biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032740 positive regulation of interleukin-17 production biological_process
GO:0032747 positive regulation of interleukin-23 production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0042127 regulation of cell proliferation biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0044130 negative regulation of growth of symbiont in host biological_process
GO:0045080 positive regulation of chemokine biosynthetic process biological_process
GO:0045087 innate immune response biological_process
GO:0045351 type I interferon biosynthetic process biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048661 positive regulation of smooth muscle cell proliferation biological_process
GO:0050671 positive regulation of lymphocyte proliferation biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0050830 defense response to Gram-positive bacterium biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0070555 response to interleukin-1 biological_process
GO:0070935 3'-UTR-mediated mRNA stabilization biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0005121 Toll binding molecular_function
GO:0005123 death receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0070976 TIR domain binding molecular_function