myeloid differentiation primary response 88
Symbol
MYD88
(may also be known as: None)
Organism
Human
Description
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Orthologs
Symbol | Species | |
---|---|---|
Myd88 | Drosophila melanogaster | |
myd88 | Danio rerio | |
Myd88 | Mus musculus | |
Myd88 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2216 | myeloid differentiation primary response gene (88) increases with age | Molecular | hippocampus | Human | MYD88 | 59.3% Increase Gene Expression Level | |
DAA2230 | myeloid differentiation primary response gene (88) increases with age | Molecular | parietal lobe | Human | MYD88 | 54.8% Increase Gene Expression Level | |
DAA2242 | myeloid differentiation primary response gene (88) increases with age | Molecular | frontal lobe | Human | MYD88 | 58.7% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | biological_process | |
GO:0002238 | response to molecule of fungal origin | biological_process | |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | biological_process | |
GO:0006916 | anti-apoptosis | biological_process | |
GO:0007165 | signal transduction | biological_process | |
GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
GO:0008063 | Toll signaling pathway | biological_process | |
GO:0009615 | response to virus | biological_process | |
GO:0016064 | immunoglobulin mediated immune response | biological_process | |
GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | biological_process | |
GO:0032494 | response to peptidoglycan | biological_process | |
GO:0032496 | response to lipopolysaccharide | biological_process | |
GO:0032740 | positive regulation of interleukin-17 production | biological_process | |
GO:0032747 | positive regulation of interleukin-23 production | biological_process | |
GO:0032755 | positive regulation of interleukin-6 production | biological_process | |
GO:0032760 | positive regulation of tumor necrosis factor production | biological_process | |
GO:0034130 | toll-like receptor 1 signaling pathway | biological_process | |
GO:0034134 | toll-like receptor 2 signaling pathway | biological_process | |
GO:0034142 | toll-like receptor 4 signaling pathway | biological_process | |
GO:0042127 | regulation of cell proliferation | biological_process | |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_process | |
GO:0044130 | negative regulation of growth of symbiont in host | biological_process | |
GO:0045080 | positive regulation of chemokine biosynthetic process | biological_process | |
GO:0045087 | innate immune response | biological_process | |
GO:0045351 | type I interferon biosynthetic process | biological_process | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
GO:0046330 | positive regulation of JNK cascade | biological_process | |
GO:0048011 | nerve growth factor receptor signaling pathway | biological_process | |
GO:0048661 | positive regulation of smooth muscle cell proliferation | biological_process | |
GO:0050671 | positive regulation of lymphocyte proliferation | biological_process | |
GO:0050727 | regulation of inflammatory response | biological_process | |
GO:0050830 | defense response to Gram-positive bacterium | biological_process | |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | biological_process | |
GO:0070555 | response to interleukin-1 | biological_process | |
GO:0070935 | 3'-UTR-mediated mRNA stabilization | biological_process | |
GO:0071260 | cellular response to mechanical stimulus | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005829 | cytosol | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0010008 | endosome membrane | cellular_component | |
GO:0005121 | Toll binding | molecular_function | |
GO:0005123 | death receptor binding | molecular_function | |
GO:0005515 | protein binding | molecular_function | |
GO:0042802 | identical protein binding | molecular_function | |
GO:0070976 | TIR domain binding | molecular_function | |