5-methyltetrahydrofolate-homocysteine methyltransferase
Symbol
MTR
(may also be known as: None)
Organism
Human
Description
This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Orthologs
Symbol | Species | |
---|---|---|
nos-1 | Caenorhabditis elegans | |
uncharacterized_E7FB | Danio rerio | |
Mtr | Mus musculus | |
Mtr | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0000096 | sulfur amino acid metabolic process | biological_process | |
GO:0006479 | protein methylation | biological_process | |
GO:0006805 | xenobiotic metabolic process | biological_process | |
GO:0007399 | nervous system development | biological_process | |
GO:0008652 | cellular amino acid biosynthetic process | biological_process | |
GO:0032259 | methylation | biological_process | |
GO:0034641 | cellular nitrogen compound metabolic process | biological_process | |
GO:0042558 | pteridine-containing compound metabolic process | biological_process | |
GO:0044237 | cellular metabolic process | biological_process | |
GO:0044281 | small molecule metabolic process | biological_process | |
GO:0046653 | tetrahydrofolate metabolic process | biological_process | |
GO:0050667 | homocysteine metabolic process | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005625 | soluble fraction | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005829 | cytosol | cellular_component | |
GO:0005542 | folic acid binding | molecular_function | |
GO:0008168 | methyltransferase activity | molecular_function | |
GO:0008270 | zinc ion binding | molecular_function | |
GO:0008705 | methionine synthase activity | molecular_function | |
GO:0008898 | homocysteine S-methyltransferase activity | molecular_function | |
GO:0016740 | transferase activity | molecular_function | |
GO:0031419 | cobalamin binding | molecular_function | |
GO:0046872 | metal ion binding | molecular_function | |