5-methyltetrahydrofolate-homocysteine methyltransferase

Symbol

MTR (may also be known as: None)

Organism

Human

Description

This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Orthologs

SymbolSpecies
nos-1 Caenorhabditis elegans
uncharacterized_E7FB Danio rerio
Mtr Mus musculus
Mtr Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3275 Gene expression of MTR increases with age Molecular skin Human MTR —

GO Terms

GO IDGO TermGO Category
GO:0000096 sulfur amino acid metabolic process biological_process
GO:0006479 protein methylation biological_process
GO:0006805 xenobiotic metabolic process biological_process
GO:0007399 nervous system development biological_process
GO:0008652 cellular amino acid biosynthetic process biological_process
GO:0032259 methylation biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0042558 pteridine-containing compound metabolic process biological_process
GO:0044237 cellular metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0046653 tetrahydrofolate metabolic process biological_process
GO:0050667 homocysteine metabolic process biological_process
GO:0005622 intracellular cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005542 folic acid binding molecular_function
GO:0008168 methyltransferase activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0008705 methionine synthase activity molecular_function
GO:0008898 homocysteine S-methyltransferase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0031419 cobalamin binding molecular_function
GO:0046872 metal ion binding molecular_function