methionine sulfoxide reductase A
Symbol
MSRA
(may also be known as: None)
Organism
Human
Description
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| msra-1 | Caenorhabditis elegans | |
| Eip71CD | Drosophila melanogaster | |
| si:dkey-221h15.1 | Danio rerio | |
| Msra | Mus musculus | |
| Msra | Rattus norvegicus | |
| MXR1 | Saccharomyces cerevisiae | |
| mxr1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006464 | protein modification process | biological_process | |
| GO:0006555 | methionine metabolic process | biological_process | |
| GO:0006979 | response to oxidative stress | biological_process | |
| GO:0007568 | aging | biological_process | |
| GO:0019538 | protein metabolic process | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0008113 | peptide-methionine-(S)-S-oxide reductase activity | molecular_function | |
| GO:0016491 | oxidoreductase activity | molecular_function | |
| GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | molecular_function | |