asparagine synthetase (glutamine-hydrolyzing)
Symbol
ASNS
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| asns-2 | Caenorhabditis elegans | |
| asparagine-synthetas | Drosophila melanogaster | |
| asns | Danio rerio | |
| Asns | Mus musculus | |
| Asns | Rattus norvegicus | |
| ASN1 | Saccharomyces cerevisiae | |
| asn1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001889 | liver development | biological_process | |
| GO:0006520 | cellular amino acid metabolic process | biological_process | |
| GO:0006529 | asparagine biosynthetic process | biological_process | |
| GO:0006541 | glutamine metabolic process | biological_process | |
| GO:0006987 | activation of signaling protein activity involved in unfolded protein response | biological_process | |
| GO:0008652 | cellular amino acid biosynthetic process | biological_process | |
| GO:0009416 | response to light stimulus | biological_process | |
| GO:0009612 | response to mechanical stimulus | biological_process | |
| GO:0009636 | response to toxin | biological_process | |
| GO:0030968 | endoplasmic reticulum unfolded protein response | biological_process | |
| GO:0031427 | response to methotrexate | biological_process | |
| GO:0031667 | response to nutrient levels | biological_process | |
| GO:0032354 | response to follicle-stimulating hormone stimulus | biological_process | |
| GO:0032870 | cellular response to hormone stimulus | biological_process | |
| GO:0034641 | cellular nitrogen compound metabolic process | biological_process | |
| GO:0042149 | cellular response to glucose starvation | biological_process | |
| GO:0043066 | negative regulation of apoptotic process | biological_process | |
| GO:0043200 | response to amino acid stimulus | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0045931 | positive regulation of mitotic cell cycle | biological_process | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016874 | ligase activity | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0048037 | cofactor binding | molecular_function | |