achaete-scute family bHLH transcription factor 2

Symbol

ASCL2 (may also be known as: None)

Organism

Human

Description

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ac Drosophila melanogaster
Ascl2 Mus musculus
Ascl2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2998 Gene expression of ASCL2 increases with age Molecular skin Human ASCL2 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001666 response to hypoxia biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001890 placenta development biological_process
GO:0006351 transcription, DNA-dependent biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007417 central nervous system development biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0010626 negative regulation of Schwann cell proliferation biological_process
GO:0030154 cell differentiation biological_process
GO:0035019 somatic stem cell maintenance biological_process
GO:0060708 spongiotrophoblast differentiation biological_process
GO:0060712 spongiotrophoblast layer development biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0070888 E-box binding molecular_function