MHC class I polypeptide-related sequence B
Symbol
MICB
(may also be known as: None)
Organism
Human
Description
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq, Jul 2008]
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2340 | MHC class I polypeptide-related sequence B increases with age | Molecular | parietal lobe | Human | MICB | 39.9% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002429 | immune response-activating cell surface receptor signaling pathway | biological_process | |
GO:0006955 | immune response | biological_process | |
GO:0006979 | response to oxidative stress | biological_process | |
GO:0009408 | response to heat | biological_process | |
GO:0019835 | cytolysis | biological_process | |
GO:0019882 | antigen processing and presentation | biological_process | |
GO:0032526 | response to retinoic acid | biological_process | |
GO:0044419 | interspecies interaction between organisms | biological_process | |
GO:0046629 | gamma-delta T cell activation | biological_process | |
GO:0050689 | negative regulation of defense response to virus by host | biological_process | |
GO:0050776 | regulation of immune response | biological_process | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0005887 | integral to plasma membrane | cellular_component | |
GO:0016020 | membrane | cellular_component | |
GO:0042612 | MHC class I protein complex | cellular_component | |
GO:0046703 | natural killer cell lectin-like receptor binding | molecular_function | |