MHC class I polypeptide-related sequence B

Symbol

MICB (may also be known as: None)

Organism

Human

Description

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2340 MHC class I polypeptide-related sequence B increases with age Molecular parietal lobe Human MICB 39.9% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002429 immune response-activating cell surface receptor signaling pathway biological_process
GO:0006955 immune response biological_process
GO:0006979 response to oxidative stress biological_process
GO:0009408 response to heat biological_process
GO:0019835 cytolysis biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0032526 response to retinoic acid biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0046629 gamma-delta T cell activation biological_process
GO:0050689 negative regulation of defense response to virus by host biological_process
GO:0050776 regulation of immune response biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0042612 MHC class I protein complex cellular_component
GO:0046703 natural killer cell lectin-like receptor binding molecular_function