malic enzyme 1, NADP(+)-dependent, cytosolic

Symbol

ME1 (may also be known as: None)

Organism

Human

Description

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Men Drosophila melanogaster
Me1 Mus musculus
Me1 Rattus norvegicus
mae2 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3262 Gene expression of ME1 decreases with age Molecular skin Human ME1 —

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006108 malate metabolic process biological_process
GO:0006741 NADP biosynthetic process biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0009743 response to carbohydrate stimulus biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051262 protein tetramerization biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005829 cytosol cellular_component
GO:0004470 malic enzyme activity molecular_function
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity molecular_function
GO:0009055 electron carrier activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016619 malate dehydrogenase (oxaloacetate-decarboxylating) activity molecular_function
GO:0030145 manganese ion binding molecular_function
GO:0043531 ADP binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050661 NADP binding molecular_function
GO:0051287 NAD binding molecular_function