MYC associated factor X

Symbol

MAX (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Orthologs

SymbolSpecies
mxl-1 Caenorhabditis elegans
Max Drosophila melanogaster
max Danio rerio
Max Mus musculus
Max Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3260 Gene expression of MAX decreases with age Molecular skin Human MAX —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006461 protein complex assembly biological_process
GO:0009267 cellular response to starvation biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0048678 response to axon injury biological_process
GO:0051402 neuron apoptosis biological_process
GO:0060041 retina development in camera-type eye biological_process
GO:0071375 cellular response to peptide hormone stimulus biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016605 PML body cellular_component
GO:0030425 dendrite cellular_component
GO:0071339 MLL1 complex cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003712 transcription cofactor activity molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0005515 protein binding molecular_function
GO:0032403 protein complex binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function