SMAD family member 7

Symbol

SMAD7 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Orthologs

SymbolSpecies
smad7 Danio rerio
Smad7 Mus musculus
Smad7 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2812 Gene expression of SMAD7 decreases with age Molecular adipose tissue Human SMAD7 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001657 ureteric bud development biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0010719 negative regulation of epithelial to mesenchymal transition biological_process
GO:0010801 negative regulation of peptidyl-threonine phosphorylation biological_process
GO:0010944 negative regulation of transcription by competitive promoter binding biological_process
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0022409 positive regulation of cell-cell adhesion biological_process
GO:0030336 negative regulation of cell migration biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0030514 negative regulation of BMP signaling pathway biological_process
GO:0031397 negative regulation of protein ubiquitination biological_process
GO:0031398 positive regulation of protein ubiquitination biological_process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0032925 regulation of activin receptor signaling pathway biological_process
GO:0033137 negative regulation of peptidyl-serine phosphorylation biological_process
GO:0034333 adherens junction assembly biological_process
GO:0034616 response to laminar fluid shear stress biological_process
GO:0034629 cellular protein complex localization biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0048844 artery morphogenesis biological_process
GO:0050821 protein stabilization biological_process
GO:0051444 negative regulation of ubiquitin-protein ligase activity biological_process
GO:0055010 ventricular cardiac muscle tissue morphogenesis biological_process
GO:0055117 regulation of cardiac muscle contraction biological_process
GO:0060373 regulation of ventricular cardiomyocyte membrane depolarization biological_process
GO:0060389 pathway-restricted SMAD protein phosphorylation biological_process
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation biological_process
GO:0060412 ventricular septum morphogenesis biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005913 cell-cell adherens junction cellular_component
GO:0016342 catenin complex cellular_component
GO:0043234 protein complex cellular_component
GO:0005515 protein binding molecular_function
GO:0005518 collagen binding molecular_function
GO:0008013 beta-catenin binding molecular_function
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0034713 type I transforming growth factor beta receptor binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0048185 activin binding molecular_function
GO:0070411 I-SMAD binding molecular_function