aryl hydrocarbon receptor nuclear translocator-like
Symbol
ARNTL
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| arntl1b | Danio rerio | |
| Arntl | Mus musculus | |
| Arntl | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000060 | protein import into nucleus, translocation | biological_process | |
| GO:0007623 | circadian rhythm | biological_process | |
| GO:0042176 | regulation of protein catabolic process | biological_process | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005667 | transcription factor complex | cellular_component | |
| GO:0000982 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0004871 | signal transducer activity | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0017162 | aryl hydrocarbon receptor binding | molecular_function | |
| GO:0051879 | Hsp90 protein binding | molecular_function | |