lymphotoxin beta (TNF superfamily, member 3)
Symbol
Organism
Description
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Ltb | Mus musculus | |
| Ltb | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006955 | immune response | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007267 | cell-cell signaling | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0043588 | skin development | biological_process | |
| GO:0045084 | positive regulation of interleukin-12 biosynthetic process | biological_process | |
| GO:0048535 | lymph node development | biological_process | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0005102 | receptor binding | molecular_function | |
| GO:0005125 | cytokine activity | molecular_function | |
| GO:0005164 | tumor necrosis factor receptor binding | molecular_function | |