ligase I, DNA, ATP-dependent

Symbol

LIG1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Orthologs

SymbolSpecies
lig-1 Caenorhabditis elegans
DNA-ligI Drosophila melanogaster
si:dkeyp-35b8.5 Danio rerio
Lig1 Mus musculus
LOC100911727 Rattus norvegicus
CDC9 Saccharomyces cerevisiae
cdc17 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3248 Gene expression of LIG1 increases with age Molecular skin Human LIG1 —

GO Terms

GO IDGO TermGO Category
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0000722 telomere maintenance via recombination biological_process
GO:0000723 telomere maintenance biological_process
GO:0000724 double-strand break repair via homologous recombination biological_process
GO:0006259 DNA metabolic process biological_process
GO:0006260 DNA replication biological_process
GO:0006266 DNA ligation biological_process
GO:0006271 DNA strand elongation involved in DNA replication biological_process
GO:0006281 DNA repair biological_process
GO:0006283 transcription-coupled nucleotide-excision repair biological_process
GO:0006284 base-excision repair biological_process
GO:0006289 nucleotide-excision repair biological_process
GO:0006297 nucleotide-excision repair, DNA gap filling biological_process
GO:0006302 double-strand break repair biological_process
GO:0006310 DNA recombination biological_process
GO:0009653 anatomical structure morphogenesis biological_process
GO:0032201 telomere maintenance via semi-conservative replication biological_process
GO:0033151 V(D)J recombination biological_process
GO:0051103 DNA ligation involved in DNA repair biological_process
GO:0051301 cell division biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003909 DNA ligase activity molecular_function
GO:0003910 DNA ligase (ATP) activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0046872 metal ion binding molecular_function