leukemia inhibitory factor

Symbol

LIF (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Orthologs

SymbolSpecies
Lif Mus musculus
Lif Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3247 Gene expression of LIF increases with age Molecular skin Human LIF —

GO Terms

GO IDGO TermGO Category
GO:0001974 blood vessel remodeling biological_process
GO:0006955 immune response biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007566 embryo implantation biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0010976 positive regulation of neuron projection development biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:0019827 stem cell maintenance biological_process
GO:0031100 organ regeneration biological_process
GO:0033138 positive regulation of peptidyl-serine phosphorylation biological_process
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein biological_process
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein biological_process
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein biological_process
GO:0043410 positive regulation of MAPKKK cascade biological_process
GO:0045595 regulation of cell differentiation biological_process
GO:0045651 positive regulation of macrophage differentiation biological_process
GO:0045835 negative regulation of meiosis biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046697 decidualization biological_process
GO:0046888 negative regulation of hormone secretion biological_process
GO:0048286 lung alveolus development biological_process
GO:0048644 muscle organ morphogenesis biological_process
GO:0048666 neuron development biological_process
GO:0048711 positive regulation of astrocyte differentiation biological_process
GO:0048861 leukemia inhibitory factor signaling pathway biological_process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0051461 positive regulation of corticotropin secretion biological_process
GO:0060041 retina development in camera-type eye biological_process
GO:0060135 maternal process involved in female pregnancy biological_process
GO:0060290 transdifferentiation biological_process
GO:0060426 lung vasculature development biological_process
GO:0060463 lung lobe morphogenesis biological_process
GO:0060707 trophoblast giant cell differentiation biological_process
GO:0060708 spongiotrophoblast differentiation biological_process
GO:0070373 negative regulation of ERK1 and ERK2 cascade biological_process
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis biological_process
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005102 receptor binding molecular_function
GO:0005125 cytokine activity molecular_function
GO:0005146 leukemia inhibitory factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function