lecithin-cholesterol acyltransferase
Symbol
LCAT
(may also be known as: None)
Organism
Human
Description
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_M05B5.4 | Caenorhabditis elegans | |
| CG18858 | Drosophila melanogaster | |
| lcat | Danio rerio | |
| Lcat | Mus musculus | |
| Lcat | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA3243 | Gene expression of LCAT increases with age | Molecular | skin | Human | LCAT | — | |
| DAA2425 | lecithin-cholesterol acyltransferase precursor decreases with age | Molecular | dermis | Human | LCAT | 18.6% Decrease DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | biological_process | |
| GO:0006644 | phospholipid metabolic process | biological_process | |
| GO:0006656 | phosphatidylcholine biosynthetic process | biological_process | |
| GO:0008202 | steroid metabolic process | biological_process | |
| GO:0008203 | cholesterol metabolic process | biological_process | |
| GO:0030301 | cholesterol transport | biological_process | |
| GO:0034372 | very-low-density lipoprotein particle remodeling | biological_process | |
| GO:0034375 | high-density lipoprotein particle remodeling | biological_process | |
| GO:0034435 | cholesterol esterification | biological_process | |
| GO:0042157 | lipoprotein metabolic process | biological_process | |
| GO:0042158 | lipoprotein biosynthetic process | biological_process | |
| GO:0042632 | cholesterol homeostasis | biological_process | |
| GO:0043691 | reverse cholesterol transport | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0046688 | response to copper ion | biological_process | |
| GO:0051384 | response to glucocorticoid stimulus | biological_process | |
| GO:0090107 | regulation of high-density lipoprotein particle assembly | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0034364 | high-density lipoprotein particle | cellular_component | |
| GO:0004607 | phosphatidylcholine-sterol O-acyltransferase activity | molecular_function | |
| GO:0004623 | phospholipase A2 activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0016746 | transferase activity, transferring acyl groups | molecular_function | |
| GO:0034186 | apolipoprotein A-I binding | molecular_function | |