laminin, beta 3
Symbol
LAMB3
(may also be known as: None)
Organism
Human
Description
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| si:ch1073-15f12.3 | Danio rerio | |
| Lamb3 | Mus musculus | |
| Lamb3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007155 | cell adhesion | biological_process | |
| GO:0008544 | epidermis development | biological_process | |
| GO:0031581 | hemidesmosome assembly | biological_process | |
| GO:0034329 | cell junction assembly | biological_process | |
| GO:0050873 | brown fat cell differentiation | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005604 | basement membrane | cellular_component | |
| GO:0005610 | laminin-5 complex | cellular_component | |
| GO:0005198 | structural molecule activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0032403 | protein complex binding | molecular_function | |