laminin, alpha 5
Symbol
Organism
Description
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| epi-1 | Caenorhabditis elegans | |
| LanA | Drosophila melanogaster | |
| lama5 | Danio rerio | |
| Lama5 | Mus musculus | |
| Lama5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001525 | angiogenesis | biological_process | |
| GO:0001658 | branching involved in ureteric bud morphogenesis | biological_process | |
| GO:0001738 | morphogenesis of a polarized epithelium | biological_process | |
| GO:0001755 | neural crest cell migration | biological_process | |
| GO:0001942 | hair follicle development | biological_process | |
| GO:0007010 | cytoskeleton organization | biological_process | |
| GO:0007229 | integrin-mediated signaling pathway | biological_process | |
| GO:0007517 | muscle organ development | biological_process | |
| GO:0008037 | cell recognition | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0009790 | embryo development | biological_process | |
| GO:0009887 | organ morphogenesis | biological_process | |
| GO:0016331 | morphogenesis of embryonic epithelium | biological_process | |
| GO:0016477 | cell migration | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0030155 | regulation of cell adhesion | biological_process | |
| GO:0030324 | lung development | biological_process | |
| GO:0030334 | regulation of cell migration | biological_process | |
| GO:0034446 | substrate adhesion-dependent cell spreading | biological_process | |
| GO:0042127 | regulation of cell proliferation | biological_process | |
| GO:0042384 | cilium assembly | biological_process | |
| GO:0042475 | odontogenesis of dentin-containing tooth | biological_process | |
| GO:0045446 | endothelial cell differentiation | biological_process | |
| GO:0045995 | regulation of embryonic development | biological_process | |
| GO:0048041 | focal adhesion assembly | biological_process | |
| GO:0060445 | branching involved in salivary gland morphogenesis | biological_process | |
| GO:0090002 | establishment of protein localization in plasma membrane | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005604 | basement membrane | cellular_component | |
| GO:0005605 | basal lamina | cellular_component | |
| GO:0005606 | laminin-1 complex | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0031012 | extracellular matrix | cellular_component | |
| GO:0043259 | laminin-10 complex | cellular_component | |
| GO:0043260 | laminin-11 complex | cellular_component | |
| GO:0005178 | integrin binding | molecular_function | |
| GO:0005198 | structural molecule activity | molecular_function | |
| GO:0005488 | binding | molecular_function | |