keratin 81

Symbol

KRT81 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
5430421N21Rik Mus musculus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0045095 keratin filament cellular_component
GO:0005198 structural molecule activity molecular_function
GO:0005515 protein binding molecular_function