arginase 2

Symbol

ARG2 (may also be known as: None)

Organism

Human

Description

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CELE_T21F4.1 Caenorhabditis elegans
arg2 Danio rerio
Arg2 Mus musculus
Arg2 Rattus norvegicus
CAR1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2994 Gene expression of ARG2 decreases with age Molecular skin Human ARG2 —

GO Terms

GO IDGO TermGO Category
GO:0000050 urea cycle biological_process
GO:0001657 ureteric bud development biological_process
GO:0001666 response to hypoxia biological_process
GO:0006525 arginine metabolic process biological_process
GO:0006809 nitric oxide biosynthetic process biological_process
GO:0006915 apoptotic process biological_process
GO:0007494 midgut development biological_process
GO:0007584 response to nutrient biological_process
GO:0009635 response to herbicide biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0009749 response to glucose stimulus biological_process
GO:0010269 response to selenium ion biological_process
GO:0010963 regulation of L-arginine import biological_process
GO:0030324 lung development biological_process
GO:0033197 response to vitamin E biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0042493 response to drug biological_process
GO:0043200 response to amino acid stimulus biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045428 regulation of nitric oxide biosynthetic process biological_process
GO:0045988 negative regulation of striated muscle contraction biological_process
GO:0046686 response to cadmium ion biological_process
GO:0046689 response to mercury ion biological_process
GO:0048678 response to axon injury biological_process
GO:0051001 negative regulation of nitric-oxide synthase activity biological_process
GO:0060135 maternal process involved in female pregnancy biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071346 cellular response to interferon-gamma biological_process
GO:0071549 cellular response to dexamethasone stimulus biological_process
GO:0005739 mitochondrion cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0004053 arginase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050998 nitric-oxide synthase binding molecular_function