killer cell lectin-like receptor subfamily B, member 1
Symbol
KLRB1
(may also be known as: None)
Organism
Human
Description
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Klrb1a | Mus musculus | |
| Klrb1a | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004888 | transmembrane signaling receptor activity | molecular_function | |
| GO:0005488 | binding | molecular_function | |
| GO:0005529 | sugar binding | molecular_function | |