inositol 1,4,5-trisphosphate receptor, type 3

Symbol

ITPR3 (may also be known as: None)

Organism

Human

Description

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

Orthologs

SymbolSpecies
itr-1 Caenorhabditis elegans
Itp-r83A Drosophila melanogaster
itpr3 Danio rerio
Itpr3 Mus musculus
Itpr3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3214 Gene expression of ITPR3 increases with age Molecular skin Human ITPR3 —

GO Terms

GO IDGO TermGO Category
GO:0006112 energy reserve metabolic process biological_process
GO:0006811 ion transport biological_process
GO:0007165 signal transduction biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007202 activation of phospholipase C activity biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007596 blood coagulation biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0030168 platelet activation biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048016 inositol phosphate-mediated signaling biological_process
GO:0050796 regulation of insulin secretion biological_process
GO:0050913 sensory perception of bitter taste biological_process
GO:0050916 sensory perception of sweet taste biological_process
GO:0050917 sensory perception of umami taste biological_process
GO:0051260 protein homooligomerization biological_process
GO:0051291 protein heterooligomerization biological_process
GO:0051592 response to calcium ion biological_process
GO:0055085 transmembrane transport biological_process
GO:0060402 calcium ion transport into cytosol biological_process
GO:0005634 nucleus cellular_component
GO:0005640 nuclear outer membrane cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0005903 brush border cellular_component
GO:0016020 membrane cellular_component
GO:0031095 platelet dense tubular network membrane cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043209 myelin sheath cellular_component
GO:0045177 apical part of cell cellular_component
GO:0000822 inositol hexakisphosphate binding molecular_function
GO:0004872 receptor activity molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005218 intracellular ligand-gated calcium channel activity molecular_function
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity molecular_function
GO:0005262 calcium channel activity molecular_function
GO:0005515 protein binding molecular_function
GO:0035091 phosphatidylinositol binding molecular_function
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding molecular_function
GO:0070679 inositol 1,4,5 trisphosphate binding molecular_function