integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Symbol

ITGA2 (may also be known as: None)

Organism

Human

Description

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Orthologs

SymbolSpecies
itga2.2 Danio rerio
Itga2 Mus musculus
Itga2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3211 Gene expression of ITGA2 increases with age Molecular skin Human ITGA2 —

GO Terms

GO IDGO TermGO Category
GO:0007155 cell adhesion biological_process
GO:0007160 cell-matrix adhesion biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007411 axon guidance biological_process
GO:0007596 blood coagulation biological_process
GO:0009887 organ morphogenesis biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0005886 plasma membrane cellular_component
GO:0008305 integrin complex cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0045178 basal part of cell cellular_component
GO:0004872 receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005518 collagen binding molecular_function