interleukin-1 receptor-associated kinase 2

Symbol

IRAK2 (may also be known as: None)

Organism

Human

Description

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
pll Drosophila melanogaster
Irak2 Mus musculus
Irak2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3207 Gene expression of IRAK2 increases with age Molecular skin Human IRAK2 —

GO Terms

GO IDGO TermGO Category
GO:0000187 activation of MAPK activity biological_process
GO:0001959 regulation of cytokine-mediated signaling pathway biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006954 inflammatory response biological_process
GO:0007165 signal transduction biological_process
GO:0007249 I-kappaB kinase/NF-kappaB cascade biological_process
GO:0007254 JNK cascade biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032088 negative regulation of NF-kappaB transcription factor activity biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0045087 innate immune response biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process
GO:0070498 interleukin-1-mediated signaling pathway biological_process
GO:0070555 response to interleukin-1 biological_process
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0010008 endosome membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function