insulin induced gene 1
Symbol
INSIG1
(may also be known as: None)
Organism
Human
Description
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| insig1 | Danio rerio | |
| Insig1 | Mus musculus | |
| LOC688922 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006641 | triglyceride metabolic process | biological_process | |
| GO:0006695 | cholesterol biosynthetic process | biological_process | |
| GO:0006991 | response to sterol depletion | biological_process | |
| GO:0008152 | metabolic process | biological_process | |
| GO:0008202 | steroid metabolic process | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0010894 | negative regulation of steroid biosynthetic process | biological_process | |
| GO:0030967 | ER-nuclear sterol response pathway | biological_process | |
| GO:0042472 | inner ear morphogenesis | biological_process | |
| GO:0042474 | middle ear morphogenesis | biological_process | |
| GO:0045599 | negative regulation of fat cell differentiation | biological_process | |
| GO:0045717 | negative regulation of fatty acid biosynthetic process | biological_process | |
| GO:0060021 | palate development | biological_process | |
| GO:0060363 | cranial suture morphogenesis | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |