interleukin 18 (interferon-gamma-inducing factor)

Symbol

IL18 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Orthologs

SymbolSpecies
Il18 Mus musculus
Il18 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2251 interleukin 18 (interferon-gamma-inducing factor) increases with age Molecular hippocampus Human IL18 68.9% Increase Gene Expression Level
DAA2260 interleukin 18 (interferon-gamma-inducing factor) increases with age Molecular parietal lobe Human IL18 56.7% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0001525 angiogenesis biological_process
GO:0001649 osteoblast differentiation biological_process
GO:0001666 response to hypoxia biological_process
GO:0006954 inflammatory response biological_process
GO:0006955 immune response biological_process
GO:0007267 cell-cell signaling biological_process
GO:0009314 response to radiation biological_process
GO:0009409 response to cold biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0030155 regulation of cell adhesion biological_process
GO:0030324 lung development biological_process
GO:0030431 sleep biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032722 positive regulation of chemokine production biological_process
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production biological_process
GO:0032729 positive regulation of interferon-gamma production biological_process
GO:0032731 positive regulation of interleukin-1 beta production biological_process
GO:0032740 positive regulation of interleukin-17 production biological_process
GO:0032757 positive regulation of interleukin-8 production biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0032819 positive regulation of natural killer cell proliferation biological_process
GO:0032930 positive regulation of superoxide anion generation biological_process
GO:0032967 positive regulation of collagen biosynthetic process biological_process
GO:0034105 positive regulation of tissue remodeling biological_process
GO:0042033 chemokine biosynthetic process biological_process
GO:0042088 T-helper 1 type immune response biological_process
GO:0042092 type 2 immune response biological_process
GO:0042094 interleukin-2 biosynthetic process biological_process
GO:0042095 interferon-gamma biosynthetic process biological_process
GO:0042104 positive regulation of activated T cell proliferation biological_process
GO:0042231 interleukin-13 biosynthetic process biological_process
GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process biological_process
GO:0043117 positive regulation of vascular permeability biological_process
GO:0043525 positive regulation of neuron apoptosis biological_process
GO:0048546 digestive tract morphogenesis biological_process
GO:0050729 positive regulation of inflammatory response biological_process
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain biological_process
GO:0051142 positive regulation of NK T cell proliferation biological_process
GO:0055093 response to hyperoxia biological_process
GO:0060312 regulation of blood vessel remodeling biological_process
GO:0070301 cellular response to hydrogen peroxide biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0071320 cellular response to cAMP biological_process
GO:0071346 cellular response to interferon-gamma biological_process
GO:0071356 cellular response to tumor necrosis factor biological_process
GO:0071374 cellular response to parathyroid hormone stimulus biological_process
GO:0071375 cellular response to peptide hormone stimulus biological_process
GO:0071407 cellular response to organic cyclic compound biological_process
GO:2000256 positive regulation of male germ cell proliferation biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0005125 cytokine activity molecular_function