interleukin 18 (interferon-gamma-inducing factor)
Symbol
IL18
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Orthologs
Symbol | Species | |
---|---|---|
Il18 | Mus musculus | |
Il18 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2251 | interleukin 18 (interferon-gamma-inducing factor) increases with age | Molecular | hippocampus | Human | IL18 | 68.9% Increase Gene Expression Level | |
DAA2260 | interleukin 18 (interferon-gamma-inducing factor) increases with age | Molecular | parietal lobe | Human | IL18 | 56.7% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0000165 | MAPKKK cascade | biological_process | |
GO:0001525 | angiogenesis | biological_process | |
GO:0001649 | osteoblast differentiation | biological_process | |
GO:0001666 | response to hypoxia | biological_process | |
GO:0006954 | inflammatory response | biological_process | |
GO:0006955 | immune response | biological_process | |
GO:0007267 | cell-cell signaling | biological_process | |
GO:0009314 | response to radiation | biological_process | |
GO:0009409 | response to cold | biological_process | |
GO:0010628 | positive regulation of gene expression | biological_process | |
GO:0030155 | regulation of cell adhesion | biological_process | |
GO:0030324 | lung development | biological_process | |
GO:0030431 | sleep | biological_process | |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | biological_process | |
GO:0032722 | positive regulation of chemokine production | biological_process | |
GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production | biological_process | |
GO:0032729 | positive regulation of interferon-gamma production | biological_process | |
GO:0032731 | positive regulation of interleukin-1 beta production | biological_process | |
GO:0032740 | positive regulation of interleukin-17 production | biological_process | |
GO:0032757 | positive regulation of interleukin-8 production | biological_process | |
GO:0032760 | positive regulation of tumor necrosis factor production | biological_process | |
GO:0032819 | positive regulation of natural killer cell proliferation | biological_process | |
GO:0032930 | positive regulation of superoxide anion generation | biological_process | |
GO:0032967 | positive regulation of collagen biosynthetic process | biological_process | |
GO:0034105 | positive regulation of tissue remodeling | biological_process | |
GO:0042033 | chemokine biosynthetic process | biological_process | |
GO:0042088 | T-helper 1 type immune response | biological_process | |
GO:0042092 | type 2 immune response | biological_process | |
GO:0042094 | interleukin-2 biosynthetic process | biological_process | |
GO:0042095 | interferon-gamma biosynthetic process | biological_process | |
GO:0042104 | positive regulation of activated T cell proliferation | biological_process | |
GO:0042231 | interleukin-13 biosynthetic process | biological_process | |
GO:0042253 | granulocyte macrophage colony-stimulating factor biosynthetic process | biological_process | |
GO:0043117 | positive regulation of vascular permeability | biological_process | |
GO:0043525 | positive regulation of neuron apoptosis | biological_process | |
GO:0048546 | digestive tract morphogenesis | biological_process | |
GO:0050729 | positive regulation of inflammatory response | biological_process | |
GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain | biological_process | |
GO:0051142 | positive regulation of NK T cell proliferation | biological_process | |
GO:0055093 | response to hyperoxia | biological_process | |
GO:0060312 | regulation of blood vessel remodeling | biological_process | |
GO:0070301 | cellular response to hydrogen peroxide | biological_process | |
GO:0071260 | cellular response to mechanical stimulus | biological_process | |
GO:0071320 | cellular response to cAMP | biological_process | |
GO:0071346 | cellular response to interferon-gamma | biological_process | |
GO:0071356 | cellular response to tumor necrosis factor | biological_process | |
GO:0071374 | cellular response to parathyroid hormone stimulus | biological_process | |
GO:0071375 | cellular response to peptide hormone stimulus | biological_process | |
GO:0071407 | cellular response to organic cyclic compound | biological_process | |
GO:2000256 | positive regulation of male germ cell proliferation | biological_process | |
GO:0005576 | extracellular region | cellular_component | |
GO:0005615 | extracellular space | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0005829 | cytosol | cellular_component | |
GO:0016324 | apical plasma membrane | cellular_component | |
GO:0005125 | cytokine activity | molecular_function | |