interleukin 11 receptor, alpha
Symbol
IL11RA
(may also be known as: None)
Organism
Human
Description
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| il11ra | Danio rerio | |
| Il11ra2 | Mus musculus | |
| Il11ra1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007165 | signal transduction | biological_process | |
| GO:0032502 | developmental process | biological_process | |
| GO:0060322 | head development | biological_process | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0004871 | signal transducer activity | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004888 | transmembrane signaling receptor activity | molecular_function | |
| GO:0004896 | cytokine receptor activity | molecular_function | |