iduronate 2-sulfatase

Symbol

IDS (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the sulfatase family, is localized to the lysosome, and is involved in lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease, mucopolysaccharidosis type II, also known as Hunter syndrome. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2013]

Orthologs

SymbolSpecies
CG12014 Drosophila melanogaster
ids Danio rerio
Ids Mus musculus
Ids Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3198 Gene expression of IDS increases with age Molecular skin Human IDS —

GO Terms

GO IDGO TermGO Category
GO:0005764 lysosome cellular_component
GO:0003824 catalytic activity molecular_function
GO:0004423 iduronate-2-sulfatase activity molecular_function
GO:0008484 sulfuric ester hydrolase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0046872 metal ion binding molecular_function