intercellular adhesion molecule 3
Symbol
ICAM3
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0016337 | cell-cell adhesion | biological_process | |
| GO:0050776 | regulation of immune response | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0005102 | receptor binding | molecular_function | |
| GO:0005178 | integrin binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |