intercellular adhesion molecule 2
Symbol
ICAM2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Icam2 | Mus musculus | |
| Icam2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0016337 | cell-cell adhesion | biological_process |
| GO:0050776 | regulation of immune response | biological_process |
| GO:0001931 | uropod | cellular_component |
| GO:0005886 | plasma membrane | cellular_component |
| GO:0005887 | integral to plasma membrane | cellular_component |
| GO:0005178 | integrin binding | molecular_function |