5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Symbol
HTR2A
(may also be known as: None)
Organism
Human
Description
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| si:dkey-276l13.4 | Danio rerio | |
| Htr2a | Mus musculus | |
| Htr2a | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001659 | temperature homeostasis | biological_process | |
| GO:0006661 | phosphatidylinositol biosynthetic process | biological_process | |
| GO:0006950 | response to stress | biological_process | |
| GO:0007208 | activation of phospholipase C activity by serotonin receptor signaling pathway | biological_process | |
| GO:0007210 | serotonin receptor signaling pathway | biological_process | |
| GO:0007268 | synaptic transmission | biological_process | |
| GO:0007568 | aging | biological_process | |
| GO:0007613 | memory | biological_process | |
| GO:0008219 | cell death | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0014059 | regulation of dopamine secretion | biological_process | |
| GO:0014065 | phosphatidylinositol 3-kinase cascade | biological_process | |
| GO:0019233 | sensory perception of pain | biological_process | |
| GO:0030431 | sleep | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0043267 | negative regulation of potassium ion transport | biological_process | |
| GO:0043406 | positive regulation of MAP kinase activity | biological_process | |
| GO:0045907 | positive regulation of vasoconstriction | biological_process | |
| GO:0051209 | release of sequestered calcium ion into cytosol | biological_process | |
| GO:0051967 | negative regulation of synaptic transmission, glutamatergic | biological_process | |
| GO:0070371 | ERK1 and ERK2 cascade | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0043198 | dendritic shaft | cellular_component | |
| GO:0004435 | phosphatidylinositol phospholipase C activity | molecular_function | |
| GO:0004871 | signal transducer activity | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004930 | G-protein coupled receptor activity | molecular_function | |
| GO:0004993 | serotonin receptor activity | molecular_function | |
| GO:0008144 | drug binding | molecular_function | |
| GO:0051378 | serotonin binding | molecular_function | |
| GO:0071886 | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding | molecular_function | |