heat shock transcription factor 4
Symbol
HSF4
(may also be known as: None)
Organism
Human
Description
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| hsf4 | Danio rerio | |
| Hsf4 | Mus musculus | |
| Hsf4 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006950 | response to stress | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0033169 | histone H3-K9 demethylation | biological_process | |
| GO:0043010 | camera-type eye development | biological_process | |
| GO:0045597 | positive regulation of cell differentiation | biological_process | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0048468 | cell development | biological_process | |
| GO:0070207 | protein homotrimerization | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003714 | transcription corepressor activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |