homeobox D12
Symbol
HOXD12
(may also be known as: None)
Organism
Human
Description
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| hoxd12a | Danio rerio | |
| Hoxd12 | Mus musculus | |
| Hoxd12 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001501 | skeletal system development | biological_process | |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007389 | pattern specification process | biological_process | |
| GO:0042733 | embryonic digit morphogenesis | biological_process | |
| GO:0000228 | nuclear chromosome | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005667 | transcription factor complex | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |