homeobox C8
Symbol
HOXC8
(may also be known as: None)
Organism
Human
Description
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| mab-5 | Caenorhabditis elegans | |
| hoxc8a | Danio rerio | |
| Hoxc8 | Mus musculus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0009952 | anterior/posterior pattern specification | biological_process | |
| GO:0030182 | neuron differentiation | biological_process | |
| GO:0048705 | skeletal system morphogenesis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |