homeobox C6

Symbol

HOXC6 (may also be known as: None)

Organism

Human

Description

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
lin-39 Caenorhabditis elegans
hoxc6a Danio rerio
Hoxc6 Mus musculus
Hoxc6 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3183 Gene expression of HOXC6 increases with age Molecular skin Human HOXC6 —

GO Terms

GO IDGO TermGO Category
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0007275 multicellular organismal development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0048706 embryonic skeletal system development biological_process
GO:0005634 nucleus cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function