homeobox C4

Symbol

HOXC4 (may also be known as: None)

Organism

Human

Description

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Scr Drosophila melanogaster
hoxc4a Danio rerio
Hoxc4 Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3182 Gene expression of HOXC4 increases with age Molecular skin Human HOXC4 —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0007275 multicellular organismal development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0048562 embryonic organ morphogenesis biological_process
GO:0051216 cartilage development biological_process
GO:0005634 nucleus cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0071837 HMG box domain binding molecular_function