high mobility group box 2

Symbol

HMGB2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
hmgb2a Danio rerio
Hmgb2 Mus musculus
Hmgb2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3177 Gene expression of HMGB2 increases with age Molecular skin Human HMGB2 —

GO Terms

GO IDGO TermGO Category
GO:0001938 positive regulation of endothelial cell proliferation biological_process
GO:0006265 DNA topological change biological_process
GO:0006288 base-excision repair, DNA ligation biological_process
GO:0006309 DNA fragmentation involved in apoptotic nuclear change biological_process
GO:0006325 chromatin organization biological_process
GO:0006334 nucleosome assembly biological_process
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0006915 apoptotic process biological_process
GO:0006921 cellular component disassembly involved in apoptosis biological_process
GO:0007283 spermatogenesis biological_process
GO:0007289 spermatid nucleus differentiation biological_process
GO:0008584 male gonad development biological_process
GO:0032075 positive regulation of nuclease activity biological_process
GO:0033151 V(D)J recombination biological_process
GO:0043388 positive regulation of DNA binding biological_process
GO:0045648 positive regulation of erythrocyte differentiation biological_process
GO:0045654 positive regulation of megakaryocyte differentiation biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0048545 response to steroid hormone stimulus biological_process
GO:0050918 positive chemotaxis biological_process
GO:0051103 DNA ligation involved in DNA repair biological_process
GO:0060326 cell chemotaxis biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0000793 condensed chromosome cellular_component
GO:0005615 extracellular space cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0043234 protein complex cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003684 damaged DNA binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003697 single-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008301 DNA binding, bending molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0042056 chemoattractant activity molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0050786 RAGE receptor binding molecular_function