major histocompatibility complex, class II, DR alpha

Symbol

HLA-DRA (may also be known as: None)

Organism

Human

Description

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
H2-Ea Mus musculus
RT1-Da Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2359 major histocompatibility complex, class II, DR alpha increases with age Molecular hippocampus Human HLA-DRA 324.5% Increase Gene Expression Level
DAA2323 major histocompatibility complex, class II, DR alpha increases with age Molecular parietal lobe Human HLA-DRA 241.7% Increase Gene Expression Level
DAA2311 major histocompatibility complex, class II, DR alpha increases with age Molecular temporal lobe Human HLA-DRA 146.7% Increase Gene Expression Level
DAA2317 major histocompatibility complex, class II, DR alpha increases with age Molecular hippocampus Human HLA-DRA 317.7% Increase Gene Expression Level
DAA2326 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 146.8% Increase Gene Expression Level
DAA2354 major histocompatibility complex, class II, DR alpha increases with age Molecular temporal lobe Human HLA-DRA 150.4% Increase Gene Expression Level
DAA2364 major histocompatibility complex, class II, DR alpha increases with age Molecular parietal lobe Human HLA-DRA 303.7% Increase Gene Expression Level
DAA2369 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 135.3% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0006955 immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0031295 T cell costimulation biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0005764 lysosome cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031902 late endosome membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component
GO:0032395 MHC class II receptor activity molecular_function