major histocompatibility complex, class II, DQ beta 1

Symbol

HLA-DQB1 (may also be known as: None)

Organism

Human

Description

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Orthologs

SymbolSpecies
H2-Ab1 Mus musculus
RT1-B Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2357 major histocompatibility complex, class II, DQ beta 1 increases with age Molecular hippocampus Human HLA-DQB1 106.0% Increase Gene Expression Level
DAA2358 major histocompatibility complex, class II, DQ beta 1 increases with age Molecular hippocampus Human HLA-DQB1 135.4% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002344 B cell affinity maturation biological_process
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0002579 positive regulation of antigen processing and presentation biological_process
GO:0002827 positive regulation of T-helper 1 type immune response biological_process
GO:0006955 immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II biological_process
GO:0031295 T cell costimulation biological_process
GO:0046635 positive regulation of alpha-beta T cell activation biological_process
GO:0048002 antigen processing and presentation of peptide antigen biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0071346 cellular response to interferon-gamma biological_process
GO:0005622 intracellular cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005769 early endosome cellular_component
GO:0005771 multivesicular body cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component
GO:0015643 toxin binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0032395 MHC class II receptor activity molecular_function
GO:0042605 peptide antigen binding molecular_function
GO:0070491 repressing transcription factor binding molecular_function