major histocompatibility complex, class II, DQ alpha 1
Symbol
Organism
Description
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Orthologs
Symbol | Species | |
---|---|---|
H2-Aa | Mus musculus | |
RT1-Ba | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2155 | Major histocompatibility complex, class II, DQ alpha 1 increases with age | Molecular | hippocampus | Human | HLA-DQA1 | 496.7% Increase Gene Expression Level | |
DAA2156 | Major histocompatibility complex, class II, DQ alpha 1 increases with age | Molecular | parietal lobe | Human | HLA-DQA1 | 203.7% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | biological_process | |
GO:0006955 | immune response | biological_process | |
GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
GO:0019882 | antigen processing and presentation | biological_process | |
GO:0031295 | T cell costimulation | biological_process | |
GO:0050852 | T cell receptor signaling pathway | biological_process | |
GO:0060333 | interferon-gamma-mediated signaling pathway | biological_process | |
GO:0005765 | lysosomal membrane | cellular_component | |
GO:0005768 | endosome | cellular_component | |
GO:0005783 | endoplasmic reticulum | cellular_component | |
GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
GO:0005794 | Golgi apparatus | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0005887 | integral to plasma membrane | cellular_component | |
GO:0010008 | endosome membrane | cellular_component | |
GO:0016020 | membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0042613 | MHC class II protein complex | cellular_component | |
GO:0032395 | MHC class II receptor activity | molecular_function | |