major histocompatibility complex, class II, DM beta

Symbol

HLA-DMB (may also be known as: None)

Organism

Human

Description

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
H2-DMb1 Mus musculus
LOC100909630 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2313 major histocompatibility complex, class II, DM beta increases with age Molecular hippocampus Human HLA-DMB 90.5% Increase Gene Expression Level
DAA2319 major histocompatibility complex, class II, DM beta increases with age Molecular parietal lobe Human HLA-DMB 57.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II biological_process
GO:0006955 immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0031295 T cell costimulation biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031902 late endosome membrane cellular_component
GO:0042613 MHC class II protein complex cellular_component