major histocompatibility complex, class II, DM beta
Symbol
Organism
Description
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Orthologs
Symbol | Species | |
---|---|---|
H2-DMb1 | Mus musculus | |
LOC100909630 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2313 | major histocompatibility complex, class II, DM beta increases with age | Molecular | hippocampus | Human | HLA-DMB | 90.5% Increase Gene Expression Level | |
DAA2319 | major histocompatibility complex, class II, DM beta increases with age | Molecular | parietal lobe | Human | HLA-DMB | 57.0% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | biological_process | |
GO:0006955 | immune response | biological_process | |
GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
GO:0019882 | antigen processing and presentation | biological_process | |
GO:0031295 | T cell costimulation | biological_process | |
GO:0050852 | T cell receptor signaling pathway | biological_process | |
GO:0060333 | interferon-gamma-mediated signaling pathway | biological_process | |
GO:0005765 | lysosomal membrane | cellular_component | |
GO:0005768 | endosome | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0016020 | membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0031902 | late endosome membrane | cellular_component | |
GO:0042613 | MHC class II protein complex | cellular_component | |