hydroxysteroid (17-beta) dehydrogenase 10

Symbol

HSD17B10 (may also be known as: None)

Organism

Human

Description

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ard-1 Caenorhabditis elegans
scu Drosophila melanogaster
hsd17b10 Danio rerio
Hsd17b10 Mus musculus
Hsd17b10 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3172 Gene expression of HSD17B10 decreases with age Molecular skin Human HSD17B10 —
DAA3171 Gene expression of HSD17B10 decreases with age Molecular skin Human HSD17B10 —

GO Terms

GO IDGO TermGO Category
GO:0006629 lipid metabolic process biological_process
GO:0007569 cell aging biological_process
GO:0008033 tRNA processing biological_process
GO:0009083 branched chain family amino acid catabolic process biological_process
GO:0033327 Leydig cell differentiation biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051289 protein homotetramerization biological_process
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005886 plasma membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001540 beta-amyloid binding molecular_function
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity molecular_function
GO:0004303 estradiol 17-beta-dehydrogenase activity molecular_function
GO:0005496 steroid binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008709 cholate 7-alpha-dehydrogenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0018454 acetoacetyl-CoA reductase activity molecular_function
GO:0030331 estrogen receptor binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity molecular_function
GO:0051287 NAD binding molecular_function