glycophorin C (Gerbich blood group)
Symbol
GYPC
(may also be known as: None)
Organism
Human
Description
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| gypc | Danio rerio | |
| Gypc | Mus musculus | |
| Gypc | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA3167 | Gene expression of GYPC decreases with age | Molecular | skin | Human | GYPC | — | |
| DAA2802 | Gene expression of GYPC decreases with age | Molecular | adipose tissue | Human | GYPC | — |
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0005886 | plasma membrane | cellular_component |
| GO:0005887 | integral to plasma membrane | cellular_component |
| GO:0030863 | cortical cytoskeleton | cellular_component |
| GO:0005515 | protein binding | molecular_function |