hook microtubule-tethering protein 2

Symbol

HOOK2 (may also be known as: None)

Organism

Human

Description

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Orthologs

SymbolSpecies
zyg-12 Caenorhabditis elegans
hk Drosophila melanogaster
Hook2 Mus musculus
Hook2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3814 Gene expression of HOOK2 increases with age Molecular skin Human HOOK2 —

GO Terms

GO IDGO TermGO Category
GO:0000226 microtubule cytoskeleton organization biological_process
GO:0006897 endocytosis biological_process
GO:0007032 endosome organization biological_process
GO:0007040 lysosome organization biological_process
GO:0008333 endosome to lysosome transport biological_process
GO:0015031 protein transport biological_process
GO:0045022 early endosome to late endosome transport biological_process
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005874 microtubule cellular_component
GO:0030897 HOPS complex cellular_component
GO:0070695 FHF complex cellular_component
GO:0005515 protein binding molecular_function
GO:0008017 microtubule binding molecular_function
GO:0042802 identical protein binding molecular_function