eukaryotic elongation factor-2 kinase

Symbol

EEF2K (may also be known as: None)

Organism

Human

Description

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
efk-1 Caenorhabditis elegans
eef2k Danio rerio
Eef2k Mus musculus
Eef2k Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3813 Gene expression of EEF2K increases with age Molecular skin Human EEF2K —

GO Terms

GO IDGO TermGO Category
GO:0006414 translational elongation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0031952 regulation of protein autophosphorylation biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004686 elongation factor-2 kinase activity molecular_function
GO:0005488 binding molecular_function
GO:0005509 calcium ion binding molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008135 translation factor activity, nucleic acid binding molecular_function