glutathione peroxidase 3 (plasma)

Symbol

GPX3 (may also be known as: None)

Organism

Human

Description

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Gpx3 Mus musculus
Gpx3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3159 Gene expression of GPX3 decreases with age Molecular skin Human GPX3 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1321 glutathione peroxidase 3 Molecular hematological system Mouse Gpx3 45.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002238 response to molecule of fungal origin biological_process
GO:0006749 glutathione metabolic process biological_process
GO:0006979 response to oxidative stress biological_process
GO:0006982 response to lipid hydroperoxide biological_process
GO:0007565 female pregnancy biological_process
GO:0010269 response to selenium ion biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0042493 response to drug biological_process
GO:0042744 hydrogen peroxide catabolic process biological_process
GO:0051289 protein homotetramerization biological_process
GO:0051412 response to corticosterone stimulus biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005625 soluble fraction cellular_component
GO:0004602 glutathione peroxidase activity molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008430 selenium binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0043295 glutathione binding molecular_function