gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Symbol
GNRH1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| Gnrh1 | Mus musculus | |
| Gnrh1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006916 | anti-apoptosis | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007267 | cell-cell signaling | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007565 | female pregnancy | biological_process | |
| GO:0008285 | negative regulation of cell proliferation | biological_process | |
| GO:0010468 | regulation of gene expression | biological_process | |
| GO:0031960 | response to corticosteroid stimulus | biological_process | |
| GO:0042698 | ovulation cycle | biological_process | |
| GO:0045471 | response to ethanol | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005179 | hormone activity | molecular_function | |
| GO:0005183 | gonadotropin hormone-releasing hormone activity | molecular_function | |